FGFR3 is key
نویسندگان
چکیده
منابع مشابه
Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas
Background Inhibitors of fibroblast growth factor receptors (FGFRs) have recently arisen as a promising treatment option for patients with FGFR alterations. Gene fusions involving FGFR3 and transforming acidic coiled-coil protein 3 (TACC3) have been detected in diffuse gliomas and other malignancies, and fusion-positive cases have responded well to FGFR inhibition. As high FGFR3 expression has ...
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The fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostral(low) to caudal(high) gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex. Overall, the forebrain structures appeared normal in Fgfr3(-/-) mice. However, cortical and hippocampal volumes were reduced by 26.7% and 16.3%...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2009
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2669